Understanding customers' holistic perception of switches in automotive human–machine interfaces

For successful new product development, it is necessary to understand the customers' holistic experience of the product beyond traditional task completion, and acceptance measures. This paper describes research in which ninety-eight UK owners of luxury saloons assessed the feel of push-switches in five luxury saloon cars both in context (in-car) and out of context (on a bench). A combination of hedonic data (i.e. a measure of ‘liking’), qualitative data and semantic differential data was collected. It was found that customers are clearly able to differentiate between switches based on the degree of liking for the samples' perceived haptic qualities, and that the assessment environment had a statistically significant effect, but that it was not universal. A factor analysis has shown that perceived characteristics of switch haptics can be explained by three independent factors defined as ‘Image’, ‘Build Quality’, and ‘Clickiness’. Preliminary steps have also been taken towards identifying whether existing theoretical frameworks for user experience may be applicable to automotive human–machine interfaces

Deployment of a company wide quality strategy in the automotive business : executive summary

Rover Group had began to address product quality in the 1980's, by collaborating with the Honda Motor Company, and commencing a "Total Quality Improvement - TQI" initiative. Whilst delivering initial improvement, it was not considered to be sufficient to sustain an organisational culture of ongoing improvement activity within the business. A five year quality strategy was created, which identified improvement milestones for each of the key business processes that drive Rover Group. A significant deployment of the quality strategy is represented by Rover's new product introduction process, which led to the creation of Project Management Policy (PMP), and a series of processes constructed as a framework known as Common Business Environment (CBE). Implementation of PMP is achieved by the mandatory requirement for new product teams to conform to the "six quality and reliability prescriptives", which are measured by adoption of a team-based self assessment process and senior management review. The Rover Group Quality Strategy demonstrates innovation in the conceptual model designed for its initial creation, and the deployment process by application of Group Judgement Theory, and the Japanese technique of "Hoshin Kanri" policy deployment. This represents a significant contribution towards the achievement of improved business results by Rover Group in aspects of product development lead time and quality

Construct Validity of the Swedish Version of the Revised Piper Fatigue Scale in an Oncology Sample—A Rasch Analysis

AbstractObjectivesFatigue is a common and distressing symptom in cancer patients due to both the disease and its treatments. The concept of fatigue is multidimensional and includes both physical and mental components. The 22-item Revised Piper Fatigue Scale (RPFS) is a multidimensional instrument developed to assess cancer-related fatigue. This study reports on the construct validity of the Swedish version of the RPFS from the perspective of Rasch measurement.MethodsThe Swedish version of the RPFS was answered by 196 cancer patients fatigued after 4 to 5 weeks of curative radiation therapy. Data from the scale were fitted to the Rasch measurement model. This involved testing a series of assumptions, including the stochastic ordering of items, local response dependency, and unidimensionality. A series of fit statistics were computed, differential item functioning (DIF) was tested, and local response dependency was accommodated through testlets.ResultsThe Behavioral, Affective and Sensory domains all satisfied the Rasch model expectations. No DIF was observed, and all domains were found to be unidimensional. The Mood/Cognitive scale failed to fit the model, and substantial multidimensionality was found. Splitting the scale between Mood and Cognitive items resolved fit to the Rasch model, and new domains were unidimensional without DIF.ConclusionsThe current Rasch analyses add to the evidence of measurement properties of the scale and show that the RPFS has good psychometric properties and works well to measure fatigue. The original four-factor structure, however, was not supported

X-ray behaviour of Circinus X-1 - I: X-ray Dips as a diagnostic of periodic behaviour

We examine the periodic nature of detailed structure (particularly dips) in the RXTE/ASM lightcurve of Circinus X-1. The significant phase wandering of the X-ray maxima suggests their identification with the response on a viscous timescale of the accretion disk to perturbation. We find that the X-ray dips provide a more accurate system clock than the maxima, and thus use these as indicators of the times of periastron passage. We fit a quadratic ephemeris to these dips, and find its predictive power for the X-ray lightcurve to be superior to ephemerides based on the radio flares and the full archival X-ray lightcurve. Under the hypothesis that the dips are tracers of the mass transfer rate from the donor, we use their occurrence rate as a function of orbital phase to explore the (as yet unconstrained) nature of the donor. The high $\dot{P}$ term in the ephemeris provides another piece of evidence that Cir X-1 is in a state of dynamical evolution, and thus is a very young post-supernova system. We further suggest that the radio ``synchrotron nebula'' immediately surrounding Cir X-1 is in fact the remnant of the event that created the compact object, and discuss briefly the evidence for and against such an interpretation.Comment: 11 pages, 11 figures, accepted for publication in MNRA

On the nature of the ultraluminous X-ray transient in Cen~A (NGC 5128)

We combine 9 ROSAT, 9 Chandra, and 2 XMM-Newton observations of the Cen~A galaxy to obtain the X-ray light curve of 1RXH J132519.8-430312 (=CXOU J132519.9$-$430317) spanning 1990 to 2003. The source reached a peak 0.1-2.4 keV flux F_X>10^{-12} ergs cm^{-2} s^{-1} during a 10~day span in 1995 July. The inferred peak isotropic luminosity of the source therefore exceeded 3 10^{39} ergs s^{-1}, which places the source in the class of ultra-luminous X-ray sources. Coherent pulsations at 13.264 Hz are detected during a second bright episode (F_X >3 times 10^{-13} ergs cm^{-2} s^{-1}) in 1999 December. The source is detected and varies significantly within three additional observations but is below the detection threshold in 7 observations. The X-ray spectrum in 1999 December is best described as a cut-off power law or a disk-blackbody (multi-colored disk). We also detect an optical source, m_F555W ~ 24.1 mag, within the Chandra error circle of 1RXH J132519.8-430312 in HST images taken 195~days before the nearest X-ray observation. The optical brightness of this source is consistent with a late O or early B star at the distance of Cen A. If the optical source is the counterpart, then the X-ray and optical behavior of 1RXH J132519.8-430312 are similar to the transient Be/X-ray pulsar A 0538-66.Comment: 7 pages, 8 figures. ApJ (accepted

A complete X-ray spectral coverage of the 2010 May-June outbursts of Circinus X-1

Circinus X-1 is a neutron-star-accreting X-ray binary in a wide (P$_{\rm orb}$ = 16.6 d), eccentric orbit. After two years of relatively low X-ray luminosity, in May 2010 Circinus X-1 went into outburst, reaching 0.4 Crab flux. This outburst lasted for about two orbital cycles and was followed by another shorter and fainter outburst in June. We focus here on the broadband X-ray spectral evolution of the source as it spans about three order of magnitudes in flux. We attempt to relate luminosity, spectral shape, local absorption, and orbital phase. We use multiple Rossi-XTE/PCA (3.0--25 keV) and Swift/XRT (1.0--9.0 keV) observations and a 20 ks long Chandra/HETGS observation (1.0--9.0 keV), to comprehensively track the spectral evolution of the source during all the outbursting phases. These observations were taken every two/three days and cover about four orbital cycles. The PCA data mostly cover the major outburst, the XRT data monitor the declining phase of the major outburst and all the phases of the minor outburst, and Chandra data provide an essential snapshot of the end of this overall outbursting phase. The X-ray spectrum can be satisfactorily described by a thermal Comptonization model with variable neutral local absorption in all phases of the outburst. No other additive component is statistically required. The first outburst decays linearly, with an ankle in the light curve as the flux decreases below $\sim$\,5 $\times$ 10$^{-10}$ erg cm$^{-2}$ s$^{-1}$. At the same time, the source shows a clear spectral state transition from an optically thick to an optically thin state. While the characteristics of the first, bright, outburst can be interpreted within the disk-instability scenario, the following, minor, outburst shows peculiarities that cannot be easily reconciled in this framework.Comment: Accepted for publication in Astronomy and Astrophysic

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Hepatitis C virus (HCV) requires the liver specific micro-RNA (miRNA), miR-122, to replicate. This was considered unique among RNA viruses until recent discoveries of HCV-related hepaciviruses prompting the question of a more general miR-122 dependence. Among hepaciviruses, the closest known HCV relative is the equine non-primate hepacivirus (NPHV). Here, we used Argonaute cross-linking immunoprecipitation (AGO-CLIP) to confirm AGO binding to the single predicted miR-122 site in the NPHV 5’UTR in vivo. To study miR-122 requirements in the absence of NPHV-permissive cell culture systems, we generated infectious NPHV/HCV chimeric viruses with the 5’ end of NPHV replacing orthologous HCV sequences. These chimeras were viable even in cells lacking miR-122, although miR-122 presence enhanced virus production. No other miRNAs bound this region. By random mutagenesis, we isolated HCV variants partially dependent on miR-122 as well as robustly replicating NPHV/HCV variants completely independent of any miRNAs. These miRNA independent variants even replicate and produce infectious particles in non-hepatic cells after exogenous delivery of apolipoprotein E (ApoE). Our findings suggest that miR-122 independent HCV and NPHV variants have arisen and been sampled during evolution, yet miR-122 dependence has prevailed. We propose that hepaciviruses may use this mechanism to guarantee liver tropism and exploit the tolerogenic liver environment to avoid clearance and promote chronicity

Global Gene Expression Associated with Hepatocarcinogenesis in Adult Male Mice Induced by in Utero Arsenic Exposure

Our previous work has shown that exposure to inorganic arsenic in utero produces hepatocellular carcinoma (HCC) in adult male mice. To explore further the molecular mechanisms of transplacental arsenic hepatocarcinogenesis, we conducted a second arsenic transplacental carcinogenesis study and used a genomewide microarray to profile arsenic-induced aberrant gene expression more extensively. Briefly, pregnant C3H mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from days 8 to 18 of gestation. The incidence of HCC in adult male offspring was increased 4-fold and tumor multiplicity 3-fold after transplacental arsenic exposure. Samples of normal liver and liver tumors were taken at autopsy for genomic analysis. Arsenic exposure in utero resulted in significant alterations (p < 0.001) in the expression of 2,010 genes in arsenic-exposed liver samples and in the expression of 2,540 genes in arsenic-induced HCC. Ingenuity Pathway Analysis revealed that significant alterations in gene expression occurred in a number of biological networks, and Myc plays a critical role in one of the primary networks. Real-time reverse transcriptase–polymerase chain reaction and Western blot analysis of selected genes/proteins showed > 90% concordance. Arsenic-altered gene expression included activation of oncogenes and HCC biomarkers, and increased expression of cell proliferation–related genes, stress proteins, and insulin-like growth factors and genes involved in cell–cell communications. Liver feminization was evidenced by increased expression of estrogen-linked genes and altered expression of genes that encode gender-related metabolic enzymes. These novel findings are in agreement with the biology and histology of arsenic-induced HCC, thereby indicating that multiple genetic events are associated with transplacental arsenic hepatocarcinogenesis

Gamma-ray Activity in the Crab Nebula: The Exceptional Flare of April 2011

The Large Area Telescope on board the Fermi satellite observed a gamma-ray flare in the Crab nebula lasting for approximately nine days in April of 2011. The source, which at optical wavelengths has a size of ~11 ly across, doubled its gamma-ray flux within eight hours. The peak photon flux was (186 +- 6) 10-7 cm-2 s-1 above 100 MeV, which corresponds to a 30-fold increase compared to the average value. During the flare, a new component emerged in the spectral energy distribution, which peaked at an energy of (375 +- 26) MeV at flare maximum. The observations imply that the emission region was likely relativistically beamed toward us and that variations in its motion are responsible for the observed spectral variability.Comment: 13 pages, 7 figures, accepted for publication in Ap